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CCR2

Quá trình sinh học	• negative regulation of adenylate cyclase activity • JAK-STAT cascade • chemokine-mediated signaling pathway • cellular calcium ion homeostasis • positive regulation of monocyte chemotaxis • dendritic cell chemotaxis • chemotaxis • blood vessel remodeling • response to wounding • Phản ứng miễn dịch • inflammatory response • GO:0022415 viral process • positive regulation of astrocyte chemotaxis • signal transduction • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • monocyte chemotaxis • positive regulation of T-helper 1 type immune response • negative regulation of type 2 immune response • humoral immune response • cellular defense response • regulation of vascular endothelial growth factor production • positive regulation of T cell chemotaxis • negative regulation of angiogenesis • nociception • cellular homeostasis • regulation of cell migration • positive regulation of interferon-gamma production • positive regulation of interleukin-2 production • T-helper 17 cell chemotaxis • negative regulation of eosinophil degranulation • positive regulation of alpha-beta T cell proliferation • homeostasis of number of cells within a tissue • positive regulation of inflammatory response • positive regulation of T cell activation • leukocyte adhesion to vascular endothelial cell • positive regulation of immune complex clearance by monocytes and macrophages • neutrophil clearance • positive regulation of leukocyte tethering or rolling • positive regulation of monocyte extravasation • positive regulation of CD8-positive, alpha-beta T cell extravasation • positive regulation of hematopoietic stem cell migration • cytokine-mediated signaling pathway • haematopoiesis • calcium-mediated signaling • cell chemotaxis • positive regulation of cold-induced thermogenesis • regulation of T cell cytokine production • monocyte extravasation • regulation of T cell differentiation • regulation of inflammatory response • positive regulation of synaptic transmission, glutamatergic • inflammatory response to wounding • macrophage migration • positive regulation of thymocyte migration • positive regulation of NMDA glutamate receptor activity
UniProt	P41597
Bản thể genChức năng phân tửThành phần tế bàoQuá trình sinh học	Bản thể gen Chức năng phân tử • CCR2 chemokine receptor binding • G-protein coupled receptor activity • protein homodimerization activity • signal transducer activity • chemokine receptor activity • C-C chemokine receptor activity • GO:0001948 protein binding • cytokine binding • chemokine (C-C motif) ligand 2 binding • chemokine (C-C motif) ligand 12 binding • chemokine (C-C motif) ligand 7 binding • chemokine binding • C-C chemokine binding Thành phần tế bào • integral component of membrane • soma • membrane • Màng tế bào • integral component of plasma membrane • neuronal cell body • sợi nhánh • perinuclear region of cytoplasm • Tế bào chất • cytosol • external side of plasma membrane Quá trình sinh học • negative regulation of adenylate cyclase activity • JAK-STAT cascade • chemokine-mediated signaling pathway • cellular calcium ion homeostasis • positive regulation of monocyte chemotaxis • dendritic cell chemotaxis • chemotaxis • blood vessel remodeling • response to wounding • Phản ứng miễn dịch • inflammatory response • GO:0022415 viral process • positive regulation of astrocyte chemotaxis • signal transduction • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • monocyte chemotaxis • positive regulation of T-helper 1 type immune response • negative regulation of type 2 immune response • humoral immune response • cellular defense response • regulation of vascular endothelial growth factor production • positive regulation of T cell chemotaxis • negative regulation of angiogenesis • nociception • cellular homeostasis • regulation of cell migration • positive regulation of interferon-gamma production • positive regulation of interleukin-2 production • T-helper 17 cell chemotaxis • negative regulation of eosinophil degranulation • positive regulation of alpha-beta T cell proliferation • homeostasis of number of cells within a tissue • positive regulation of inflammatory response • positive regulation of T cell activation • leukocyte adhesion to vascular endothelial cell • positive regulation of immune complex clearance by monocytes and macrophages • neutrophil clearance • positive regulation of leukocyte tethering or rolling • positive regulation of monocyte extravasation • positive regulation of CD8-positive, alpha-beta T cell extravasation • positive regulation of hematopoietic stem cell migration • cytokine-mediated signaling pathway • haematopoiesis • calcium-mediated signaling • cell chemotaxis • positive regulation of cold-induced thermogenesis • regulation of T cell cytokine production • monocyte extravasation • regulation of T cell differentiation • regulation of inflammatory response • positive regulation of synaptic transmission, glutamatergic • inflammatory response to wounding • macrophage migration • positive regulation of thymocyte migration • positive regulation of NMDA glutamate receptor activity Nguồn: Amigo / QuickGO
RefSeq (protein)	NP_001116513 NP_001116868 NP_001116868.1
Chức năng phân tử	• CCR2 chemokine receptor binding • G-protein coupled receptor activity • protein homodimerization activity • signal transducer activity • chemokine receptor activity • C-C chemokine receptor activity • GO:0001948 protein binding • cytokine binding • chemokine (C-C motif) ligand 2 binding • chemokine (C-C motif) ligand 12 binding • chemokine (C-C motif) ligand 7 binding • chemokine binding • C-C chemokine binding
Loài	Người
RefSeq (mRNA)	NM_001123041 NM_001123396
Danh pháp	CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C motif chemokine receptor 2
ID ngoài	OMIM: 601267 HomoloGene: 537 GeneCards: CCR2
PubMed	[1]
PDB	Tìm trên Human UniProt: PDBe RCSB
Thành phần tế bào	• integral component of membrane • soma • membrane • Màng tế bào • integral component of plasma membrane • neuronal cell body • sợi nhánh • perinuclear region of cytoplasm • Tế bào chất • cytosol • external side of plasma membrane
Danh sách mã id PDB	Danh sách mã id PDB 1KAD, 1KP1
Ensembl	ENSG00000121807
Vị trí gen (UCSC)	n/a
Entrez	729230
Cấu trúc được biết đếnPDBDanh sách mã id PDB	Cấu trúc được biết đến PDB Tìm trên Human UniProt: PDBe RCSB Danh sách mã id PDB 1KAD, 1KP1

Thực đơn

CCR2 Chức năng Xem thêm Tham khảo Gen Đọc thêm Ý nghĩa lâm sàng Nghiên cứu động vật Liên kết ngoài

Liên quan

CCR2 CCR4 CCR9 CCR1 CCR3 (gen) CCR8 (gen) CCR5 CCR

Tài liệu tham khảo

WikiPedia: CCR2 //pubmed.ncbi.nlm.nih.gov/10985245 //pubmed.ncbi.nlm.nih.gov/15053339 //pubmed.ncbi.nlm.nih.gov/17351623 //pubmed.ncbi.nlm.nih.gov/20136653 //pubmed.ncbi.nlm.nih.gov/20955439 //pubmed.ncbi.nlm.nih.gov/22607625 //pubmed.ncbi.nlm.nih.gov/25934927 //pubmed.ncbi.nlm.nih.gov/28663258 //pubmed.ncbi.nlm.nih.gov/30687011 //pubmed.ncbi.nlm.nih.gov/8048929