Thụ_thể_androgen

Thụ_thể_androgen

Thụ_thể_androgen

Thụ_thể_androgen

1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6 367n/aENSG00000169083n/aP10275
Q9NUA2n/aNM_001011645
NM_000044
NM_001348061
NM_001348063
NM_001348064n/aNP_000035.2
NP_001011645.1n/aThụ thể androgen (AR), còn được gọi là NR3C4 (phân họ thụ thể hạt nhân 3, nhóm C, thành viên 4), là một loại thụ thể nhân được kích hoạt bằng cách liên kết với bất kỳ hormone androgen nào, bao gồm testosterone và dihydrotestosterone trong tế bào chất và sau đó di chuyển vào nhân. Thụ thể androgen có liên quan chặt chẽ nhất với thụ thể progesterone và proestin ở liều cao hơn có thể ngăn chặn thụ thể androgen.[3][4]Chức năng chính của thụ thể androgen là yếu tố phiên mã gắn DNA điều chỉnh biểu hiện gen; tuy nhiên, thụ thể androgen cũng có các chức năng khác. Các gen quy định androgen rất quan trọng cho sự phát triển và duy trì kiểu hình tình dục nam.

Thụ_thể_androgen

Quá trình sinh học

• negative regulation of cell proliferation
• positive regulation of cell differentiation
• positive regulation of NF-kappaB transcription factor activity
• sex differentiation
• signal transduction
• negative regulation of integrin biosynthetic process
• cell-cell signaling
• intracellular receptor signaling pathway
• prostate gland development
• positive regulation of integrin biosynthetic process
• positive regulation of phosphorylation
• androgen receptor signaling pathway
• positive regulation of gene expression
• positive regulation of cell proliferation
• positive regulation of transcription, DNA-templated
• negative regulation of extrinsic apoptotic signaling pathway
• transcription initiation from RNA polymerase II promoter
• regulation of transcription, DNA-templated
• cellular proliferation
• cell growth
• positive regulation of transcription from RNA polymerase III promoter
• protein oligomerization
• transcription, DNA-templated
• positive regulation of insulin-like growth factor receptor signaling pathway
• male somatic sex determination
• positive regulation of intracellular estrogen receptor signaling pathway
• negative regulation of epithelial cell proliferation
• regulation of gene expression
• regulation of systemic arterial blood pressure
• positive regulation of transcription from RNA polymerase II promoter
• animal organ formation
• multicellular organism growth
• positive regulation of MAPK cascade
• in utero embryonic development
• reproductive system development
• tertiary branching involved in mammary gland duct morphogenesis
• cellular process
• male gonad development
• single fertilization
• Thụ tinh
• regulation of prostatic bud formation
• mammary gland alveolus development
• epithelial cell differentiation involved in prostate gland development
• epithelial cell morphogenesis
• regulation of transcription from RNA polymerase II promoter
• seminiferous tubule development
• morphogenesis of an epithelial fold
• prostate gland epithelium morphogenesis
• Leydig cell differentiation
• reproductive structure development
• GO:0048552 regulation of catalytic activity
• regulation of developmental growth
• lateral sprouting involved in mammary gland duct morphogenesis
• male genitalia morphogenesis
• prostate gland growth
• activation of prostate induction by androgen receptor signaling pathway
• Sự tạo tinh
• protein deubiquitination
• positive regulation of epithelial cell proliferation involved in prostate gland development
• negative regulation of transcription from RNA polymerase II promoter
• cellular response to steroid hormone stimulus
• cellular response to testosterone stimulus
• regulation of protein localization to plasma membrane

Mẫu hình biểu hiện RNA

Mẫu hình biểu hiện RNA

Thêm nguồn tham khảo về sự biểu hiện

UniProt


P10275 Q9NUA2

Bản thể genChức năng phân tửThành phần tế bàoQuá trình sinh học

Bản thể gen
Chức năng phân tử	• metal ion binding • lipid binding • receptor binding • sequence-specific DNA binding • RNA polymerase II transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein dimerization activity • chromatin binding • zinc ion binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • ATPase binding • androgen binding • steroid binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001948 protein binding • DNA binding • beta-catenin binding • POU domain binding • enzyme binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II basal transcription factor binding • steroid hormone receptor activity
Thành phần tế bào	• Chất nhân • Tế bào chất • cytosol • nhân tế bào • nuclear chromatin • Màng tế bào • nuclear speck • macromolecular complex
Quá trình sinh học	• negative regulation of cell proliferation • positive regulation of cell differentiation • positive regulation of NF-kappaB transcription factor activity • sex differentiation • signal transduction • negative regulation of integrin biosynthetic process • cell-cell signaling • intracellular receptor signaling pathway • prostate gland development • positive regulation of integrin biosynthetic process • positive regulation of phosphorylation • androgen receptor signaling pathway • positive regulation of gene expression • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • negative regulation of extrinsic apoptotic signaling pathway • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • cellular proliferation • cell growth • positive regulation of transcription from RNA polymerase III promoter • protein oligomerization • transcription, DNA-templated • positive regulation of insulin-like growth factor receptor signaling pathway • male somatic sex determination • positive regulation of intracellular estrogen receptor signaling pathway • negative regulation of epithelial cell proliferation • regulation of gene expression • regulation of systemic arterial blood pressure • positive regulation of transcription from RNA polymerase II promoter • animal organ formation • multicellular organism growth • positive regulation of MAPK cascade • in utero embryonic development • reproductive system development • tertiary branching involved in mammary gland duct morphogenesis • cellular process • male gonad development • single fertilization • Thụ tinh • regulation of prostatic bud formation • mammary gland alveolus development • epithelial cell differentiation involved in prostate gland development • epithelial cell morphogenesis • regulation of transcription from RNA polymerase II promoter • seminiferous tubule development • morphogenesis of an epithelial fold • prostate gland epithelium morphogenesis • Leydig cell differentiation • reproductive structure development • GO:0048552 regulation of catalytic activity • regulation of developmental growth • lateral sprouting involved in mammary gland duct morphogenesis • male genitalia morphogenesis • prostate gland growth • activation of prostate induction by androgen receptor signaling pathway • Sự tạo tinh • protein deubiquitination • positive regulation of epithelial cell proliferation involved in prostate gland development • negative regulation of transcription from RNA polymerase II promoter • cellular response to steroid hormone stimulus • cellular response to testosterone stimulus • regulation of protein localization to plasma membrane
Nguồn: Amigo / QuickGO

Kết thúc

67,730,619 bp [1]

Loài

Người

Chức năng phân tử

• metal ion binding
• lipid binding
• receptor binding
• sequence-specific DNA binding
• RNA polymerase II transcription factor binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• protein dimerization activity
• chromatin binding
• zinc ion binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• ATPase binding
• androgen binding
• steroid binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• transcription factor binding
• GO:0001948 protein binding
• DNA binding
• beta-catenin binding
• POU domain binding
• enzyme binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II basal transcription factor binding
• steroid hormone receptor activity

Danh pháp

AR, AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor

RefSeq (mRNA)


NM_001011645 NM_000044 NM_001348061 NM_001348063 NM_001348064

ID ngoài

OMIM: 313700 HomoloGene: 28 GeneCards: AR

PubMed

NST

Nhiễm sắc thể X (người)[1]

PDB

Tìm trên Human UniProt: PDBe RCSB

Thành phần tế bào

• Chất nhân
• Tế bào chất
• cytosol
• nhân tế bào
• nuclear chromatin
• Màng tế bào
• nuclear speck
• macromolecular complex

Vị trí gen (Người)NSTBăngBắt đầuKết thúc

Vị trí gen (Người)

NST	Nhiễm sắc thể X (người)[1]

Băng	Xq12	Bắt đầu	67,544,021 bp [1]
Kết thúc	67,730,619 bp [1]

Danh sách mã id PDB

Danh sách mã id PDB

1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6

BăngBắt đầu

Xq12

RefSeq (protein)NP_000035NP_001011645NP_001334990NP_001334992NP_001334993

NP_000035 NP_001011645 NP_001334990 NP_001334992 NP_001334993
NP_000035.2 NP_001011645.1

Ensembl


ENSG00000169083

Entrez


367

Vị trí gen (UCSC)

Chr X: 67.54 – 67.73 Mb

Cấu trúc được biết đếnPDBDanh sách mã id PDB

Cấu trúc được biết đến

Tìm trên Human UniProt: PDBe RCSB

Danh sách mã id PDB

1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6

Liên quan

Thụ tinh nhân tạo Thụ thể bắt cặp với G protein Thụ tinh Thụ thể hormone giải phóng gonadotropin Thụ tinh trong Thụ thể dopamine Thụ tinh kép Thụ thể (hóa sinh) Thụ thể serotonin Thụ tinh trong ống nghiệm

Tài liệu tham khảo

WikiPedia: Thụ_thể_androgen //pubmed.ncbi.nlm.nih.gov/12600226 //pubmed.ncbi.nlm.nih.gov/6371845 http://biogps.org/gene/367/ //doi.org/10.1016%2F0163-7258(83)90023-2 //doi.org/10.2165%2F00003495-200363050-00003 http://May2017.archive.ensembl.org/Homo_sapiens/Ge... http://www.ensembl.org/Homo_sapiens/geneview?gene=... http://www.genenames.org/cgi-bin/gene_symbol_repor... http://amigo.geneontology.org/ http://amigo.geneontology.org/amigo/term/GO:000012...