HRAS
HRAS

HRAS

121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B303265n/aENSG00000276536
ENSG00000174775n/aP01112n/aNM_001130442
NM_005343
NM_176795
NM_001318054n/aNP_001123914
NP_001304983
NP_005334
NP_789765n/aGTPase HRas hay transforming protein p21 là một enzyme người được mã hóa bởi gen HRAS.[3][4] Các gen HRAS nằm trên cánh ngắn (p) của nhiễm sắc thể 11 tại vị trí 15.5, từ cặp 522,241 đến cặp 525,549.[5] HRas là một G protein nhỏ trong họ gen RAS của GTPases nhỏ. Khi gắn với Guanosine triphosphate, H-Ras sẽ hoạt hóa một Raf kinase như c-Raf, bước tiếp theo trong con đường MAPK/ERK.

HRAS

Quá trình sinh học negative regulation of neuron apoptotic process
defense response to protozoan
positive regulation of protein phosphorylation
regulation of long-term neuronal synaptic plasticity
Nhập bào
positive regulation of MAP kinase activity
positive regulation of miRNA metabolic process
positive regulation of epithelial cell proliferation
positive regulation of ruffle assembly
mitotic cell cycle checkpoint signaling
positive regulation of cell migration
ephrin receptor signaling pathway
positive regulation of wound healing
positive regulation of Ras protein signal transduction
positive regulation of interferon-gamma production
stimulatory C-type lectin receptor signaling pathway
positive regulation of JNK cascade
negative regulation of gene expression
MAPK cascade
cell aging
intrinsic apoptotic signaling pathway
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
chemotaxis
cell surface receptor signaling pathway
positive regulation of gene expression
GO:0034259 negative regulation of GTPase activity
positive regulation of cell population proliferation
positive regulation of ERK1 and ERK2 cascade
animal organ morphogenesis
T-helper 1 type immune response
Ras protein signal transduction
cell population proliferation
T cell receptor signaling pathway
positive regulation of actin cytoskeleton reorganization
positive regulation of MAPK cascade
negative regulation of cell population proliferation
positive regulation of transcription by RNA polymerase II
signal transduction
Chết rụng tế bào
small GTPase mediated signal transduction
cellular senescence
response to isolation stress
cellular response to gamma radiation
positive regulation of DNA replication
positive regulation of phospholipase C activity
protein heterooligomerization
positive regulation of protein targeting to membrane
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Mẫu hình biểu hiện RNA
Mẫu hình biểu hiện RNA




Thêm nguồn tham khảo về sự biểu hiện
UniProt

P01112

Bản thể genChức năng phân tửThành phần tế bàoQuá trình sinh học
Bản thể gen
Chức năng phân tửnucleotide binding
protein C-terminus binding
GO:0001948 protein binding
GO:0006184 GTPase activity
GTP binding
GDP binding
Thành phần tế bàoTế bào chất
cytosol
bộ máy Golgi
intracellular membrane-bounded organelle
membrane
Golgi membrane
Màng tế bào
perinuclear region of cytoplasm
nhân tế bào
glutamatergic synapse
Quá trình sinh họcnegative regulation of neuron apoptotic process
defense response to protozoan
positive regulation of protein phosphorylation
regulation of long-term neuronal synaptic plasticity
Nhập bào
positive regulation of MAP kinase activity
positive regulation of miRNA metabolic process
positive regulation of epithelial cell proliferation
positive regulation of ruffle assembly
mitotic cell cycle checkpoint signaling
positive regulation of cell migration
ephrin receptor signaling pathway
positive regulation of wound healing
positive regulation of Ras protein signal transduction
positive regulation of interferon-gamma production
stimulatory C-type lectin receptor signaling pathway
positive regulation of JNK cascade
negative regulation of gene expression
MAPK cascade
cell aging
intrinsic apoptotic signaling pathway
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
chemotaxis
cell surface receptor signaling pathway
positive regulation of gene expression
GO:0034259 negative regulation of GTPase activity
positive regulation of cell population proliferation
positive regulation of ERK1 and ERK2 cascade
animal organ morphogenesis
T-helper 1 type immune response
Ras protein signal transduction
cell population proliferation
T cell receptor signaling pathway
positive regulation of actin cytoskeleton reorganization
positive regulation of MAPK cascade
negative regulation of cell population proliferation
positive regulation of transcription by RNA polymerase II
signal transduction
Chết rụng tế bào
small GTPase mediated signal transduction
cellular senescence
response to isolation stress
cellular response to gamma radiation
positive regulation of DNA replication
positive regulation of phospholipase C activity
protein heterooligomerization
positive regulation of protein targeting to membrane
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Nguồn: Amigo / QuickGO
Kết thúc 537,321 bp[1]
Chức năng phân tử nucleotide binding
protein C-terminus binding
GO:0001948 protein binding
GO:0006184 GTPase activity
GTP binding
GDP binding
Loài Người
RefSeq (protein)

NP_001123914
NP_001304983
NP_005334
NP_789765

Danh pháp HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, Ki-Ras, c-Ki-ras, KRAS2, KRAS, c-K-ras, RASK2
RefSeq (mRNA)

NM_001130442
NM_005343
NM_176795
NM_001318054

ID ngoài OMIM: 190020 HomoloGene: 55890 GeneCards: HRAS
PubMed [2]
NST Nhiễm sắc thể 11 (người)[1]
PDB Tìm trên Human UniProt: PDBe RCSB
Thành phần tế bào Tế bào chất
cytosol
bộ máy Golgi
intracellular membrane-bounded organelle
membrane
Golgi membrane
Màng tế bào
perinuclear region of cytoplasm
nhân tế bào
glutamatergic synapse
Danh sách mã id PDB
Danh sách mã id PDB

121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30

Vị trí gen (Người)NSTBăngBắt đầuKết thúc
Vị trí gen (Người)
NSTNhiễm sắc thể 11 (người)[1]
Băng11p15.5Bắt đầu532,242 bp[1]
Kết thúc537,321 bp[1]
BăngBắt đầu 11p15.5
Ensembl

ENSG00000276536
ENSG00000174775

Vị trí gen (UCSC) Chr 11: 0.53 – 0.54 Mb
Entrez

3265

Cấu trúc được biết đếnPDBDanh sách mã id PDB
Cấu trúc được biết đến
PDBTìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB

121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30